Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols.
نویسندگان
چکیده
Nitrite is an important reservoir of nitric oxide activity in the plasma and cells. Using a biomimetic model, we demonstrate the conversion of zinc-bound nitrite in the tris(pyrazolyl)borate complex (iPr2)TpZn(NO2) to the corresponding S-nitrosothiol RSNO and zinc thiolate (iPr2)TpZn-SR via reaction with thiols H-SR. Decomposition of the S-nitrosothiol formed releases nitric oxide gas.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 2 شماره
صفحات -
تاریخ انتشار 2014